› 2kas

Solution NMR

HNE-dG adduct mismatched with dA in basic solution

Released:
DOI: 10.2210/pdb2kas/pdb
PDB entry 2kas coloured by chain, front view.
PDB entry 2kas coloured by chain, side view.
PDB entry 2kas coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
Conformational interconversion of the trans-4-hydroxynonenal-derived (6S,8R,11S) 1,N(2)-deoxyguanosine adduct when mismatched with deoxyadenosine in DNA.
Huang H, Wang H, Lloyd RS, Rizzo CJ, Stone MP
Chem Res Toxicol 22 187-200 (2009)
PMID: 19053179

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-115463 (preferred)
Entry contents:
2 distinct DNA molecules
Macromolecules (2 distinct):
5'-D(*DGP*DCP*DTP*DAP*DGP*DCP*DGP*DAP*DGP*DTP*DCP*DC)-3' Chain: A
Molecule details ›
Chain: A
Length: 12 nucleotides
Theoretical weight: 3.66 KDa
Source organism: Synthetic construct
Expression system: Not provided
5'-D(*DGP*DGP*DAP*DCP*DTP*DAP*DGP*DCP*DTP*DAP*DGP*DC)-3' Chain: B
Molecule details ›
Chain: B
Length: 12 nucleotides
Theoretical weight: 3.69 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand HND 1 x HND
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Not provided

Quick links

Citations

4 review citations

Chemistry and biology of DNA containing 1,N(2)-deoxyguanosine adducts of the alpha,beta-unsaturated aldehydes acrolein, crotonaldehyde, and 4-hydroxynonenal.
Minko et al. (2009)
3 more

1 mention without citation

Chemistry and structural biology of DNA damage and biological consequences.
Stone et al. (2011)