› 2kls

Solution NMR

Apo-form of the second Ca2+ binding domain of NCX1.4

Released:
DOI: 10.2210/pdb2kls/pdb
PDB entry 2kls coloured by chain, ensemble of 20 models, front view.
PDB entry 2kls coloured by chain, ensemble of 20 models, side view.
PDB entry 2kls coloured by chain, ensemble of 20 models, top view.
Source organism: Canis lupus familiaris
Primary publication:
Ca2+ regulation in the Na+/Ca2+ exchanger features a dual electrostatic switch mechanism.
Hilge M, Aelen J, Foarce A, Perrakis A, Vuister GW
Proc Natl Acad Sci U S A 106 14333-8 (2009)
PMID: 19667209

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-162830 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sodium/calcium exchanger 1 Chain: A
Molecule details ›
Chain: A
Length: 164 amino acids
Theoretical weight: 18.73 KDa
Source organism: Canis lupus familiaris
Expression system: Escherichia coli
Structure domains: Immunoglobulin-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: Escherichia coli

Quick links

Citations

14 review citations

The SLC8 gene family of sodium-calcium exchangers (NCX) - structure, function, and regulation in health and disease.
Khananshvili D. (2013)
13 more

4 mentions without citation

Ca2+ regulation of ion transport in the Na+/Ca2+ exchanger.
Hilge M. (2012)
3 more