› 2kny

Solution NMR

Fusion construct of CR17 from LRP-1 and ApoE residues 130-149

Released:
DOI: 10.2210/pdb2kny/pdb
PDB entry 2kny coloured by chain, ensemble of 20 models, front view.
PDB entry 2kny coloured by chain, ensemble of 20 models, side view.
PDB entry 2kny coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the minimal interface between ApoE and LRP.
Guttman M, Prieto JH, Handel TM, Domaille PJ, Komives EA
J Mol Biol 398 306-19 (2010)
PMID: 20303980

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-135990 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Apolipoprotein E; Low-density lipoprotein receptor-related protein 1 515 kDa subunit Chain: A
Molecule details ›
Chain: A
Length: 80 amino acids
Theoretical weight: 8.4 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q07954 (Residues: 2770-2817; Coverage: 1%)
  • Canonical: P02649 (Residues: 147-167; Coverage: 7%)
Gene names: A2MR, APOE, APR, LRP1
Sequence domains: Low-density lipoprotein receptor domain class A

Ligands and Environments

1 bound ligand:
Ligand CA 1 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: DGSA-distance geometry simulated annealing
Expression system: Escherichia coli

Quick links

Citations

12 review citations

Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies.
Yamazaki et al. (2019)
11 more

4 mentions without citation

Structure of the minimal interface between ApoE and LRP.
Guttman et al. (2010)
3 more