› 2lfl

Solution NMR

NMR solution structure of the intermediate IIIb of TdPI-short

Released:
DOI: 10.2210/pdb2lfl/pdb
PDB entry 2lfl coloured by chain, ensemble of 20 models, front view.
PDB entry 2lfl coloured by chain, ensemble of 20 models, side view.
PDB entry 2lfl coloured by chain, ensemble of 20 models, top view.
Source organism: Rhipicephalus appendiculatus
Primary publication:
Oxidative folding and structural analyses of a Kunitz-related inhibitor and its disulfide intermediates: functional implications.
Bronsoms S, Pantoja-Uceda D, Gabrijelcic-Geiger D, Sanglas L, Aviles FX, Santoro J, Sommerhoff CP, Arolas JL
J Mol Biol 414 427-41 (2011)
PMID: 22033478

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172815 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tryptase inhibitor Chain: A
Molecule details ›
Chain: A
Length: 57 amino acids
Theoretical weight: 6.34 KDa
Source organism: Rhipicephalus appendiculatus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q1EG59 (Residues: 42-96; Coverage: 57%)
Structure domains: Pancreatic trypsin inhibitor Kunitz domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 49%
Refinement method: molecular dynamics, torsion angle dynamics
Expression system: Escherichia coli

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Citations

5 review citations

Deciphering Biological Processes at the Tick-Host Interface Opens New Strategies for Treatment of Human Diseases.
Štibrániová et al. (2019)
4 more