› 2lwn

Solution NMR

Solution Structure of Duplex DNA Containing a b-Carba-Fapy-dG Lesion

Released:
DOI: 10.2210/pdb2lwn/pdb
PDB entry 2lwn coloured by chain, ensemble of 20 models, front view.
PDB entry 2lwn coloured by chain, ensemble of 20 models, side view.
PDB entry 2lwn coloured by chain, ensemble of 20 models, top view.
Source organism: Synthetic construct
Primary publication:
Solution structure of duplex DNA containing a β-carba-Fapy-dG lesion.
Lukin M, Zaliznyak T, Attaluri S, Johnson F, de Los Santos C
Chem Res Toxicol 25 2423-31 (2012)
PMID: 22897814

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-115570 (preferred)
Entry contents:
2 distinct DNA molecules
Macromolecules (2 distinct):
DNA (5'-D(*CP*GP*TP*AP*C*(LWM)P*CP*AP*TP*GP*C)-3') Chain: B
Molecule details ›
Chain: B
Length: 11 nucleotides
Theoretical weight: 3.35 KDa
Source organism: Synthetic construct
Expression system: Not provided
DNA (5'-D(*GP*CP*AP*TP*GP*CP*GP*TP*AP*CP*G)-3') Chain: D
Molecule details ›
Chain: D
Length: 11 nucleotides
Theoretical weight: 3.37 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 31%
Refinement method: molecular dynamics
Expression system: Not provided

Quick links

Citations

8 citation in other articles

Structural Basis for Error-Free Bypass of the 5-N-Methylformamidopyrimidine-dG Lesion by Human DNA Polymerase η and Sulfolobus solfataricus P2 Polymerase IV.
Patra et al. (2015)
7 more

1 mention without citation

Solution structure of duplex DNA containing a β-carba-Fapy-dG lesion.
Lukin et al. (2012)