› 2lxo

Solution NMR

Identification of the Structural Traits Mediating the Antimicrobial Activity of a Chimeric Peptide of HBD2 and HBD3

Released:
DOI: 10.2210/pdb2lxo/pdb
PDB entry 2lxo coloured by chain, ensemble of 20 models, front view.
PDB entry 2lxo coloured by chain, ensemble of 20 models, side view.
PDB entry 2lxo coloured by chain, ensemble of 20 models, top view.
Source organism: synthetic construct
Primary publication:
Identification of structural traits that increase the antimicrobial activity of a chimeric peptide of human β-defensins 2 and 3.
Spudy B, Sönnichsen FD, Waetzig GH, Grötzinger J, Jung S
Biochem Biophys Res Commun 427 207-11 (2012)
PMID: 22995312

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-162937 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Chimeric Peptide Chain: A
Molecule details ›
Chain: A
Length: 44 amino acids
Theoretical weight: 4.98 KDa
Source organism: synthetic construct
Expression system: Not provided
Structure domains: Antimicrobial Peptide, Beta-defensin 2; Chain A

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 34%
Refinement method: simulated annealing, torsion angle dynamics
Expression system: Not provided

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Citations

1 review citation

Antibacterial polymeric nanostructures for biomedical applications.
Chen et al. (2014)
5 other articles

2 mentions without citation

Immunoinformatics approaches to explore Helicobacter Pylori proteome (Virulence Factors) to design B and T cell multi-epitope subunit vaccine.
Khan et al. (2019)
1 more