› 2m2y

Solution NMR

Solution structure of the antimicrobial peptide Btd-2[3,4]

Released:
DOI: 10.2210/pdb2m2y/pdb
PDB entry 2m2y coloured by chain, ensemble of 20 models, front view.
PDB entry 2m2y coloured by chain, ensemble of 20 models, side view.
PDB entry 2m2y coloured by chain, ensemble of 20 models, top view.
Source organism: Synthetic construct
Primary publication:
The cyclic cystine ladder in θ-defensins is important for structure and stability, but not antibacterial activity.
Conibear AC, Rosengren KJ, Daly NL, Henriques ST, Craik DJ
J Biol Chem 288 10830-40 (2013)
PMID: 23430740

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-162957 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
BTD-2[3,4] Chain: A
Molecule details ›
Chain: A
Length: 18 amino acids
Theoretical weight: 2.09 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 67%
Refinement method: simulated annealing, torsion angle dynamics
Expression system: Not provided

Quick links

Citations

15 review citations

Antimicrobial peptides: mechanism of action, activity and clinical potential.
Zhang et al. (2021)
14 more

2 mentions without citation

The cyclic cystine ladder in θ-defensins is important for structure and stability, but not antibacterial activity.
Conibear et al. (2013)
1 more