› 2mms

Solution NMR

AG(7-deaza)G FAPY modified duplex

Released:
DOI: 10.2210/pdb2mms/pdb
PDB entry 2mms coloured by chain, front view.
PDB entry 2mms coloured by chain, side view.
PDB entry 2mms coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
DNA Sequence Modulates Geometrical Isomerism of the trans-8,9- Dihydro-8-(2,6-diamino-4-oxo-3,4-dihydropyrimid-5-yl-formamido)- 9-hydroxy Aflatoxin B1 Adduct.
Li L, Brown KL, Ma R, Stone MP
OpenAccess logo Chem Res Toxicol 28 225-37 (2015)
PMID: 25587868

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-115629 (preferred)
Entry contents:
2 distinct DNA molecules
Macromolecules (2 distinct):
DNA_(5'-D(*CP*TP*AP*AP*(FAG)P*(7GU)P*TP*TP*CP*A)-3') Chain: A
Molecule details ›
Chain: A
Length: 10 nucleotides
Theoretical weight: 3.39 KDa
Source organism: Synthetic construct
Expression system: Not provided
DNA_(5'-D(*TP*GP*AP*AP*CP*CP*TP*TP*AP*G)-3') Chain: B
Molecule details ›
Chain: B
Length: 10 nucleotides
Theoretical weight: 3.04 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
1 modified residue:
Ligand 7GU 1 x 7GU

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 27%
Refinement method: DGSA-distance geometry simulated annealing
Expression system: Not provided

Quick links

Citations

2 review citations

Impact of DNA lesion repair, replication and formation on the mutational spectra of environmental carcinogens: Aflatoxin B1 as a case study.
Fedeles et al. (2018)
1 more

2 mentions without citation

Treatment of autosomal dominant hearing loss by in vivo delivery of genome editing agents.
Gao et al. (2018)
1 more