› 2mpl

Solution NMR

Solution structure of the PR domain of FOG-1

Released:
DOI: 10.2210/pdb2mpl/pdb
PDB entry 2mpl coloured by chain, ensemble of 20 models, front view.
PDB entry 2mpl coloured by chain, ensemble of 20 models, side view.
PDB entry 2mpl coloured by chain, ensemble of 20 models, top view.
Source organism: Mus musculus
Primary publication:
The identification and structure of an N-terminal PR domain show that FOG1 is a member of the PRDM family of proteins.
Clifton MK, Westman BJ, Thong SY, O'Connell MR, Webster MW, Shepherd NE, Quinlan KG, Crossley M, Blobel GA, Mackay JP
OpenAccess logo PLoS One 9 e106011 (2014)
PMID: 25162672

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-128696 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Zinc finger protein ZFPM1 Chain: A
Molecule details ›
Chain: A
Length: 127 amino acids
Theoretical weight: 14.06 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: O35615 (Residues: 100-226; Coverage: 13%)
Gene names: Fog, Fog1, Zfpm1
Sequence domains: Zinc finger protein ZFPM1-like, PR domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 87%
Refinement method: torsion angle dynamics, simulated annealing
Expression system: Escherichia coli BL21

Quick links

Citations

3 review citations

Multifaceted Role of PRDM Proteins in Human Cancer.
Casamassimi et al. (2020)
2 more

1 mention without citation

The identification and structure of an N-terminal PR domain show that FOG1 is a member of the PRDM family of proteins.
Clifton et al. (2014)