› 2mxo

Solution NMR

NMR structure of spider toxin- G7W/N24S mutant of TRTX-Hhn2b

Released:
DOI: 10.2210/pdb2mxo/pdb
PDB entry 2mxo coloured by chain, ensemble of 20 models, front view.
PDB entry 2mxo coloured by chain, ensemble of 20 models, side view.
PDB entry 2mxo coloured by chain, ensemble of 20 models, top view.
Source organism: Haplopelma hainanum
Primary publication:
Rational Engineering Defines a Molecular Switch That Is Essential for Activity of Spider-Venom Peptides against the Analgesics Target NaV1.7.
Klint JK, Chin YK, Mobli M
Mol Pharmacol 88 1002-10 (2015)
PMID: 26429937

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-112434 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mu-theraphotoxin-Hhn2b 3 Chain: A
Molecule details ›
Chain: A
Length: 34 amino acids
Theoretical weight: 3.79 KDa
Source organism: Haplopelma hainanum
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: D2Y1X8 (Residues: 49-81; Coverage: 53%)
Sequence domains: Ion channel inhibitory toxin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 95%
Refinement method: torsion angle dynamics
Expression system: Escherichia coli BL21

Quick links

Citations

8 review citations

NaV1.7 as a pain target - From gene to pharmacology.
Vetter et al. (2017)
7 more

1 mention without citation

Structure-Function and Therapeutic Potential of Spider Venom-Derived Cysteine Knot Peptides Targeting Sodium Channels.
Cardoso et al. (2019)