› 2mxs

Solution NMR

Solution NMR-structure of the neomycin sensing riboswitch RNA bound to paromomycin

Released:
DOI: 10.2210/pdb2mxs/pdb
PDB entry 2mxs coloured by chain, ensemble of 20 models, front view.
PDB entry 2mxs coloured by chain, ensemble of 20 models, side view.
PDB entry 2mxs coloured by chain, ensemble of 20 models, top view.
Source organism: Synthetic construct
Primary publication:
What a Difference an OH Makes: Conformational Dynamics as the Basis for the Ligand Specificity of the Neomycin-Sensing Riboswitch.
Duchardt-Ferner E, Gottstein-Schmidtke SR, Weigand JE, Ohlenschläger O, Wurm JP, Hammann C, Suess B, Wöhnert J
Angew Chem Int Ed Engl 55 1527-30 (2016)
PMID: 26661511

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-196513 (preferred)
Entry contents:
1 distinct RNA molecule
Macromolecule:
RNA (27-MER) Chain: A
Molecule details ›
Chain: A
Length: 27 nucleotides
Theoretical weight: 8.56 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand PAR 1 x PAR
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 83%
Refinement method: torsion angle dynamics, energy minimization
Expression system: Not provided

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Citations

1 review citation

Design of Artificial Riboswitches as Biosensors.
Findeiß et al. (2017)
20 other articles

6 mentions without citation

Recent Advances in Developing Small Molecules Targeting Nucleic Acid.
Wang et al. (2016)
5 more