› 2nls

X-ray diffraction
0.98Å resolution

Human beta-defensin-1 (Mutant Gln24Ala)

Released:
DOI: 10.2210/pdb2nls/pdb
PDB entry 2nls coloured by chain, front view.
PDB entry 2nls coloured by chain, side view.
PDB entry 2nls coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Studies of the biological properties of human beta-defensin 1.
Pazgier M, Prahl A, Hoover DM, Lubkowski J
J Biol Chem 282 1819-29 (2007)
PMID: 17071614

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157949 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Beta-defensin 1 Chain: A
Molecule details ›
Chain: A
Length: 36 amino acids
Theoretical weight: 3.94 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P60022 (Residues: 33-68; Coverage: 77%)
Gene names: BD1, DEFB1, HBD1
Sequence domains: Beta defensin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-BM
Spacegroup: P212121
Unit cell:
a: 18.81Å b: 20.32Å c: 75.12Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.106 0.105 0.124
Expression system: Escherichia coli

Quick links

Citations

6 review citations

Topical antimicrobials for burn wound infections.
Dai et al. (2010)
5 more

16 mentions without citation

The use of therapeutic peptides to target and to kill cancer cells.
Boohaker et al. (2012)
15 more