› 2nv3

Solution NMR

Solution structure of L8A mutant of HIV-1 myristoylated matrix protein

Released:
DOI: 10.2210/pdb2nv3/pdb
PDB entry 2nv3 coloured by chain, ensemble of 20 models, front view.
PDB entry 2nv3 coloured by chain, ensemble of 20 models, side view.
PDB entry 2nv3 coloured by chain, ensemble of 20 models, top view.
Source organism: Human immunodeficiency virus 1
Primary publication:
Point mutations in the HIV-1 matrix protein turn off the myristyl switch.
Saad JS, Loeliger E, Luncsford P, Liriano M, Tai J, Kim A, Miller J, Joshi A, Freed EO, Summers MF
J Mol Biol 366 574-85 (2007)
PMID: 17188710

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-179562 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Immunodeficiency lentiviral matrix N-terminal domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 131 amino acids
Theoretical weight: 14.69 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Escherichia coli
UniProt:
  • Canonical: Q6E183 (Residues: 2-132; Coverage: 87%)
Gene name: gag
Sequence domains: gag gene protein p17 (matrix protein)
Structure domains: Immunodeficiency lentiviruses, gag gene matrix protein p17

Ligands and Environments

1 bound ligand:
Ligand MYR 1 x MYR
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: distance geometry
Expression system: Escherichia coli

Quick links

Citations

19 review citations

HIV-1 assembly, budding, and maturation.
Sundquist et al. (2012)
18 more

2 mentions without citation

Point mutations in the HIV-1 matrix protein turn off the myristyl switch.
Saad et al. (2007)
1 more