› 2pdz

Solution NMR

SOLUTION STRUCTURE OF THE SYNTROPHIN PDZ DOMAIN IN COMPLEX WITH THE PEPTIDE GVKESLV, NMR, 15 STRUCTURES

Released:
DOI: 10.2210/pdb2pdz/pdb
PDB entry 2pdz coloured by chain, ensemble of 15 models, front view.
PDB entry 2pdz coloured by chain, ensemble of 15 models, side view.
PDB entry 2pdz coloured by chain, ensemble of 15 models, top view.
Source organism: Mus musculus
Primary publication:
Specific interactions between the syntrophin PDZ domain and voltage-gated sodium channels.
Schultz J, Hoffmüller U, Krause G, Ashurst J, Macias MJ, Schmieder P, Schneider-Mergener J, Oschkinat H
Nat Struct Biol 5 19-24 (1998)
PMID: 9437424

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-163160 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Alpha-1-syntrophin Chain: A
Molecule details ›
Chain: A
Length: 86 amino acids
Theoretical weight: 9.26 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q61234 (Residues: 79-164; Coverage: 17%)
Gene names: Snt1, Snta1
Sequence domains: PDZ domain
Structure domains: Pdz3 Domain
PEPTIDE GVKESLV Chain: B
Molecule details ›
Chain: B
Length: 5 amino acids
Theoretical weight: 576 Da
Source organism: Mus musculus
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

26 review citations

PDZ domains and the organization of supramolecular complexes.
Sheng et al. (2001)
25 more

11 mentions without citation

Emerging Themes in PDZ Domain Signaling: Structure, Function, and Inhibition.
Liu et al. (2019)
10 more