› 2qe3

X-ray diffraction
2.5Å resolution

Crystal structure of human tl1a extracellular domain

Released:
DOI: 10.2210/pdb2qe3/pdb
PDB entry 2qe3 coloured by chain, front view.
PDB entry 2qe3 coloured by chain, side view.
PDB entry 2qe3 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Biochemical and structural characterization of the human TL1A ectodomain.
Zhan C, Yan Q, Patskovsky Y, Li Z, Toro R, Meyer A, Cheng H, Brenowitz M, Nathenson SG, Almo SC
Biochemistry 48 7636-45 (2009)
PMID: 19522538

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131828 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tumor necrosis factor ligand superfamily member 15, secreted form Chain: A
Molecule details ›
Chain: A
Length: 184 amino acids
Theoretical weight: 20.91 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O95150 (Residues: 72-251; Coverage: 72%)
Gene names: TL1, TNFSF15, VEGI
Sequence domains: TNF(Tumour Necrosis Factor) family
Structure domains: Jelly Rolls

Ligands and Environments

1 bound ligand:
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P4132
Unit cell:
a: 120.404Å b: 120.404Å c: 120.404Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.211 0.209 0.263
Expression system: Escherichia coli

Quick links

Citations

8 review citations

Structural principles of tumor necrosis factor superfamily signaling.
Vanamee et al. (2018)
7 more

2 mentions without citation

Mechanistic basis for functional promiscuity in the TNF and TNF receptor superfamilies: structure of the LIGHT:DcR3 assembly.
Liu et al. (2014)
1 more