› 2qs3

X-ray diffraction
1.76Å resolution

Crystal structure of the GluR5 ligand binding core dimer in complex with UBP316 at 1.76 Angstroms resolution

Released:
DOI: 10.2210/pdb2qs3/pdb
PDB entry 2qs3 coloured by chain, front view.
PDB entry 2qs3 coloured by chain, side view.
PDB entry 2qs3 coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
ACET is a highly potent and specific kainate receptor antagonist: characterisation and effects on hippocampal mossy fibre function.
Dargan SL, Clarke VR, Alushin GM, Sherwood JL, Nisticò R, Bortolotto ZA, Ogden AM, Bleakman D, Doherty AJ, Lodge D, Mayer ML, Fitzjohn SM, Jane DE, Collingridge GL
Neuropharmacology 56 121-30 (2009)
PMID: 18789344

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149794 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor ionotropic, kainate 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 258 amino acids
Theoretical weight: 29.21 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P22756 (Residues: 446-559, 682-821; Coverage: 28%)
Gene names: Glur5, Grik1
Sequence domains:
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

3 bound ligands:
Ligand CL 2 x CL
Ligand 1PE 2 x 1PE
Ligand UBE 2 x UBE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: C2221
Unit cell:
a: 97.766Å b: 97.702Å c: 128.604Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.189 0.187 0.218
Expression system: Escherichia coli

Quick links

Citations

11 review citations

Glutamate receptor ion channels: structure, regulation, and function.
Traynelis et al. (2010)
10 more

4 mentions without citation

Ligand pose and orientational sampling in molecular docking.
Coleman et al. (2013)
3 more