› 2uzn

X-ray diffraction
2.3Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150313 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cyclin-dependent kinase 2 Chain: A
Molecule details ›
Chain: A
Length: 298 amino acids
Theoretical weight: 33.98 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P24941 (Residues: 1-298; Coverage: 100%)
Gene names: CDK2, CDKN2
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand C96 1 x C96
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH3R
Spacegroup: P212121
Unit cell:
a: 53.591Å b: 71.454Å c: 72.284Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.206 0.199 0.297
Expression system: Spodoptera frugiperda

Quick links

Citations

4 review citations

Application of NMR and molecular docking in structure-based drug discovery.
Stark et al. (2012)
3 more

2 mentions without citation

Molden 2.0: quantum chemistry meets proteins.
Schaftenaar et al. (2017)
1 more