Function and Biology Details
Reaction catalysed:
Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assemblies composition:
PDBe Complex ID:
PDB-CPX-138112 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Histone deacetylase 8
Molecule details ›
Chains: A, B
Length: 388 amino acids
Theoretical weight: 43.16 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Histone deacetylase domain
Structure domains: Histone deacetylase domain
Length: 388 amino acids
Theoretical weight: 43.16 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
Q9BY41 (Residues: 1-377; Coverage: 100%)
Sequence domains: Histone deacetylase domain
Structure domains: Histone deacetylase domain
Cellular tumor antigen p53
Molecule details ›
Chains: I, L
Length: 6 amino acids
Theoretical weight: 837 Da
Source organism: synthetic construct
Expression system: Not provided
UniProt:
Length: 6 amino acids
Theoretical weight: 837 Da
Source organism: synthetic construct
Expression system: Not provided
UniProt:
- Canonical: P04637 (Residues: 379-382; Coverage: 1%)
