› 2wbf

X-ray diffraction
1.6Å resolution

Crystal Structure Analysis of SERA5E from plasmodium falciparum with loop 690-700 ordered

Released:
DOI: 10.2210/pdb2wbf/pdb
PDB entry 2wbf coloured by chain, front view.
PDB entry 2wbf coloured by chain, side view.
PDB entry 2wbf coloured by chain, top view.
Source organism: Plasmodium falciparum
Primary publication:
Structural insights into the protease-like antigen Plasmodium falciparum SERA5 and its noncanonical active-site serine.
Hodder AN, Malby RL, Clarke OB, Fairlie WD, Colman PM, Crabb BS, Smith BJ
J Mol Biol 392 154-65 (2009)
PMID: 19591843

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193587 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
p50 Chain: X
Molecule details ›
Chain: X
Length: 265 amino acids
Theoretical weight: 30.67 KDa
Source organism: Plasmodium falciparum
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9TY95 (Residues: 563-827; Coverage: 27%)
Gene names: PFB0340c, SERA5
Sequence domains: Papain family cysteine protease
Structure domains: Cysteine proteinases

Ligands and Environments

3 bound ligands:
Ligand DMS 6 x DMS
Ligand CA 2 x CA
Ligand CL 4 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: R3
Unit cell:
a: 102.36Å b: 102.36Å c: 71.4Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.153 0.152 0.18
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

6 review citations

Proteases as regulators of pathogenesis: examples from the Apicomplexa.
Li et al. (2012)
5 more

2 mentions without citation

Global diversity and balancing selection of 23 leading Plasmodium falciparum candidate vaccine antigens.
Naung et al. (2022)
1 more