› 2wdu

X-ray diffraction
1.62Å resolution

Fasciola hepatica sigma class GST

Released:
DOI: 10.2210/pdb2wdu/pdb
PDB entry 2wdu coloured by chain, front view.
PDB entry 2wdu coloured by chain, side view.
PDB entry 2wdu coloured by chain, top view.
Source organism: Fasciola hepatica
Entry authors: Line K, Isupov MN, LaCourse EJ, Brophy PM, Littlechild JA

Function and Biology Details

Reaction catalysed: 
RX + glutathione = HX + R-S-glutathione
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170417 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
glutathione transferase Chains: A, B
Molecule details ›
Chains: A, B
Length: 211 amino acids
Theoretical weight: 24.57 KDa
Source organism: Fasciola hepatica
Expression system: Escherichia coli
UniProt:
  • Canonical: Q06A71 (Residues: 1-211; Coverage: 100%)
Sequence domains: Glutathione S-transferase, C-terminal domain
Structure domains:

Ligands and Environments


Cofactor: Ligand GDS 2 x GDS

Cofactor: Ligand GSH 2 x GSH
2 bound ligands:
Ligand DMS 5 x DMS
Ligand BR 8 x BR
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SIEMENS ROTATING ANODE COPPER K ALPHA
Spacegroup: P212121
Unit cell:
a: 53.947Å b: 87.419Å c: 93.988Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.193 0.191 0.224
Expression system: Escherichia coli

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