› 2yzl

X-ray diffraction
2.2Å resolution

Crystal structure of phosphoribosylaminoimidazole-succinocarboxamide synthase with ADP from Methanocaldococcus jannaschii

Released:
DOI: 10.2210/pdb2yzl/pdb
PDB entry 2yzl coloured by chain, front view.
PDB entry 2yzl coloured by chain, side view.
PDB entry 2yzl coloured by chain, top view.
Source organism: Methanocaldococcus jannaschii
Entry authors: Kanagawa M, Baba S, Fukui K, Kuramitsu S, Yokoyama S, Kawai G, Sampei G, RIKEN Structural Genomics/Proteomics Initiative (RSGI)

Function and Biology Details

Reaction catalysed: 
ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-176723 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phosphoribosylaminoimidazole-succinocarboxamide synthase Chain: A
Molecule details ›
Chain: A
Length: 242 amino acids
Theoretical weight: 27.8 KDa
Source organism: Methanocaldococcus jannaschii
Expression system: Escherichia coli
UniProt:
  • Canonical: Q58987 (Residues: 1-242; Coverage: 100%)
Gene names: MJ1592, purC
Sequence domains: SAICAR synthetase
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand SO4 2 x SO4
Ligand ADP 1 x ADP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL26B2
Spacegroup: P41212
Unit cell:
a: 82.31Å b: 82.31Å c: 85.21Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.228 0.228 0.248
Expression system: Escherichia coli

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