› 2z2c

X-ray diffraction
2.05Å resolution

MURA inhibited by unag-cnicin adduct

Released:
DOI: 10.2210/pdb2z2c/pdb
PDB entry 2z2c coloured by chain, front view.
PDB entry 2z2c coloured by chain, side view.
PDB entry 2z2c coloured by chain, top view.
Source organism: Escherichia coli
Entry authors: Steinbach A, Skarzynski T, Scheidig AJ, Klein CD

Function and Biology Details

Reaction catalysed: 
Phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-141534 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
UDP-N-acetylglucosamine 1-carboxyvinyltransferase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 423 amino acids
Theoretical weight: 45.34 KDa
Source organism: Escherichia coli
Expression system: Escherichia coli
UniProt:
  • Canonical: P0A749 (Residues: 1-419; Coverage: 100%)
Gene names: JW3156, b3189, murA, murZ
Sequence domains: EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
Structure domains: Enolpyruvate transferase domain

Ligands and Environments

2 bound ligands:
Ligand UDP 4 x UDP
Ligand UDC 4 x UDC
1 modified residue:
Ligand IAS 4 x IAS

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X12
Spacegroup: P1
Unit cell:
a: 65.127Å b: 80.369Å c: 84.871Å
α: 108.69° β: 111.07° γ: 101.17°
R-values:
R R work R free
0.195 0.191 0.271
Expression system: Escherichia coli

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