› 2zjg

X-ray diffraction
3Å resolution

Crystal structural of mouse kynurenine aminotransferase III

Released:
DOI: 10.2210/pdb2zjg/pdb
PDB entry 2zjg coloured by chain, front view.
PDB entry 2zjg coloured by chain, side view.
PDB entry 2zjg coloured by chain, top view.
Source organism: Mus musculus
Entry authors: Han Q, Cai T, Tagle DA, Robinson H, Li J

Function and Biology Details

Reactions catalysed: 
(1a) L-kynurenine + glyoxylate = 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine 
(1a) L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate
(1a) an L-cysteine-S-conjugate = a thiol + 2-aminoporp-2-enoate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180753 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Kynurenine--oxoglutarate transaminase 3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 410 amino acids
Theoretical weight: 46.45 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q71RI9 (Residues: 42-451; Coverage: 90%)
Gene names: Ccbl2, Kat3, Kyat3
Sequence domains: Aminotransferase class I and II
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand GOL 9 x GOL
1 modified residue:
Ligand LLP 2 x LLP

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P43212
Unit cell:
a: 91.09Å b: 91.09Å c: 233.05Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.222 0.222 0.233
Expression system: Spodoptera frugiperda

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