› 380d

X-ray diffraction
2Å resolution

BINDING OF THE MODIFIED DAUNORUBICIN WP401 ADJACENT TO A T-G BASE PAIR INDUCES THE REVERSE WATSON-CRICK CONFORMATION: CRYSTAL STRUCTURES OF THE WP401-TGGCCG AND WP401-CGG[BR5C]CG COMPLEXES

Released:
DOI: 10.2210/pdb380d/pdb
PDB entry 380d coloured by chain, front view.
PDB entry 380d coloured by chain, side view.
PDB entry 380d coloured by chain, top view.
Source organism: Unidentified
Primary publication:
Binding of the modified daunorubicin WP401 adjacent to a T-G base pair induces the reverse Watson-Crick conformation: crystal structures of the WP401-TGGCCG and WP401-CGG[br5C]CG complexes.
Dutta R, Gao YG, Priebe W, Wang AH
Nucleic Acids Res 26 3001-5 (1998)
PMID: 9611247

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-116038 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
DNA (5'-D(*CP*GP*(G49)P*(CBR)P*CP*G)-3') Chains: A, B
Molecule details ›
Chains: A, B
Length: 6 nucleotides
Theoretical weight: 1.9 KDa
Source organism: Unidentified
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand DM8 2 x DM8
2 modified residues:
Ligand G49 2 x G49
Ligand CBR 2 x CBR

Experiments and Validation Details

Entry percentile scores
Spacegroup: P43212
Unit cell:
a: 37.23Å b: 37.23Å c: 61.96Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.193 0.189 0.242
Expression system: Not provided

Quick links

Citations

1 review citation

Drug-DNA recognition: energetics and implications for design.
Haq et al. (2000)
3 other articles

2 mentions without citation

Unraveling the sequence-dependent polymorphic behavior of d(CpG) steps in B-DNA.
Dans et al. (2014)
1 more