› 3adt

X-ray diffraction
2.7Å resolution

Human PPARgamma ligand-binding domain in complex with 5-hydroxy-indole acetate

Released:
DOI: 10.2210/pdb3adt/pdb
PDB entry 3adt coloured by chain, front view.
PDB entry 3adt coloured by chain, side view.
PDB entry 3adt coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The nuclear receptor PPARγ individually responds to serotonin- and fatty acid-metabolites.
Waku T, Shiraki T, Oyama T, Maebara K, Nakamori R, Morikawa K
EMBO J 29 3395-407 (2010)
PMID: 20717101

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153379 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peroxisome proliferator-activated receptor gamma Chains: A, B
Molecule details ›
Chains: A, B
Length: 287 amino acids
Theoretical weight: 32.69 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P37231 (Residues: 223-505; Coverage: 56%)
Gene names: NR1C3, PPARG
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:
Ligand HID 2 x HID
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL38B1
Spacegroup: C2
Unit cell:
a: 92.992Å b: 60.893Å c: 118.222Å
α: 90° β: 103.22° γ: 90°
R-values:
R R work R free
0.215 0.215 0.283
Expression system: Escherichia coli

Quick links

Citations

20 review citations

Endogenous ligands for nuclear receptors: digging deeper.
Schupp et al. (2010)
19 more

2 mentions without citation

The nuclear receptor PPARγ individually responds to serotonin- and fatty acid-metabolites.
Waku et al. (2010)
1 more