› 3bjw

X-ray diffraction
2.3Å resolution

Crystal Structure of ecarpholin S complexed with suramin

Released:
DOI: 10.2210/pdb3bjw/pdb
PDB entry 3bjw coloured by chain, front view.
PDB entry 3bjw coloured by chain, side view.
PDB entry 3bjw coloured by chain, top view.
Source organism: Echis carinatus
Primary publication:
Structural characterization of myotoxic ecarpholin S from Echis carinatus venom.
Zhou X, Tan TC, Valiyaveettil S, Go ML, Kini RM, Velazquez-Campoy A, Sivaraman J
Biophys J 95 3366-80 (2008)
PMID: 18586854

Function and Biology Details

Reaction catalysed: 
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo octamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155791 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Basic phospholipase A2 homolog ecarpholin S Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 122 amino acids
Theoretical weight: 13.84 KDa
Source organism: Echis carinatus
UniProt:
  • Canonical: P48650 (Residues: 1-122; Coverage: 100%)
Sequence domains: Phospholipase A2
Structure domains: Phospholipase A2 domain

Ligands and Environments

1 bound ligand:
Ligand SVR 12 x SVR
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH3R
Spacegroup: P21
Unit cell:
a: 51.45Å b: 132.25Å c: 86.1Å
α: 90° β: 99.33° γ: 90°
R-values:
R R work R free
0.217 0.217 0.275

Quick links

Citations

4 review citations

Grading the commercial optical biosensor literature-Class of 2008: 'The Mighty Binders'.
Rich et al. (2010)
3 more

5 mentions without citation

100 Years of Suramin.
Wiedemar et al. (2020)
4 more