3c57

X-ray diffraction
1.7Å resolution

Crystal Structure of the Mycobacterium tuberculosis Hypoxic Response Regulator DosR C-terminal Domain Crystal Form II

Released:

Function and Biology Details

Structure analysis Details

Assemblies composition:
homo dimer
monomeric (preferred)
PDBe Complex ID:
PDB-CPX-161787 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
DNA-binding transcriptional activator DevR/DosR Chains: A, B
Molecule details ›
Chains: A, B
Length: 95 amino acids
Theoretical weight: 10.51 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P9WMF9 (Residues: 144-217; Coverage: 34%)
Gene names: Rv3133c, devR, dosR
Sequence domains: Bacterial regulatory proteins, luxR family
Structure domains: Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.2
Spacegroup: P212121
Unit cell:
a: 39.637Å b: 47.4Å c: 66.436Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.189 0.188 0.206
Expression system: Escherichia coli BL21(DE3)