› 3cc0

X-ray diffraction
1.75Å resolution

The Dvl2 PDZ Domain in Complex with the N3 Inhibitory Peptide

Released:
DOI: 10.2210/pdb3cc0/pdb
PDB entry 3cc0 coloured by chain, front view.
PDB entry 3cc0 coloured by chain, side view.
PDB entry 3cc0 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Inhibition of Wnt signaling by Dishevelled PDZ peptides.
Zhang Y, Appleton BA, Wiesmann C, Lau T, Costa M, Hannoush RN, Sidhu SS
Nat Chem Biol 5 217-9 (2009)
PMID: 19252499

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127035 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Segment polarity protein dishevelled homolog DVL-2 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 108 amino acids
Theoretical weight: 11.48 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O14641 (Residues: 264-354; Coverage: 12%)
Gene name: DVL2
Sequence domains: PDZ domain
Structure domains: Pdz3 Domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P65
Unit cell:
a: 52.617Å b: 52.617Å c: 171.098Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.19 0.188 0.238
Expression system: Escherichia coli

Quick links

Citations

33 review citations

Wnt/beta-catenin signaling: components, mechanisms, and diseases.
MacDonald et al. (2009)
32 more

6 mentions without citation

PDZ Domains as Drug Targets.
Christensen et al. (2019)
5 more