› 3cfm

X-ray diffraction
1.6Å resolution

Crystal structure of the apo form of human wild-type transthyretin

Released:
DOI: 10.2210/pdb3cfm/pdb
PDB entry 3cfm coloured by chain, front view.
PDB entry 3cfm coloured by chain, side view.
PDB entry 3cfm coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Identification of a novel ligand binding motif in the transthyretin channel.
Lima LM, Silva Vde A, Palmieri Lde C, Oliveira MC, Foguel D, Polikarpov I
Bioorg Med Chem 18 100-10 (2010)
PMID: 19954984

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
homo tetramer
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136167 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transthyretin Chains: A, B
Molecule details ›
Chains: A, B
Length: 118 amino acids
Theoretical weight: 12.96 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P02766 (Residues: 30-147; Coverage: 93%)
Gene names: PALB, TTR
Sequence domains: HIUase/Transthyretin family
Structure domains: Transthyretin/hydroxyisourate hydrolase domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU ULTRAX 18
Spacegroup: P21212
Unit cell:
a: 43.169Å b: 86.109Å c: 63.764Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.192 0.191 0.218
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Boron in drug discovery: carboranes as unique pharmacophores in biologically active compounds.
Issa et al. (2011)
10 other articles

2 mentions without citation

Enthalpy-Driven Stabilization of Transthyretin by AG10 Mimics a Naturally Occurring Genetic Variant That Protects from Transthyretin Amyloidosis.
Miller et al. (2018)
1 more