› 3cj7

X-ray diffraction
1.8Å resolution

Structure of Rattus norvegicus NTPDase2 in complex with AMP

Released:
DOI: 10.2210/pdb3cj7/pdb
PDB entry 3cj7 coloured by chain, front view.
PDB entry 3cj7 coloured by chain, side view.
PDB entry 3cj7 coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Structural insight into signal conversion and inactivation by NTPDase2 in purinergic signaling.
Zebisch M, Sträter N
Proc Natl Acad Sci U S A 105 6882-7 (2008)
PMID: 18458329

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-128713 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ectonucleoside triphosphate diphosphohydrolase 2 Chain: A
Molecule details ›
Chain: A
Length: 456 amino acids
Theoretical weight: 50.61 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: O35795 (Residues: 29-461; Coverage: 88%)
Gene names: Cd39l1, Entpd2
Sequence domains: GDA1/CD39 (nucleoside phosphatase) family
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand AMP 1 x AMP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X12
Spacegroup: P212121
Unit cell:
a: 41.07Å b: 68.903Å c: 163.83Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.17 0.17 0.206
Expression system: Escherichia coli

Quick links

Citations

6 review citations

Possible effects of microbial ecto-nucleoside triphosphate diphosphohydrolases on host-pathogen interactions.
Sansom et al. (2008)
5 more

3 mentions without citation

Cellular function and molecular structure of ecto-nucleotidases.
Zimmermann et al. (2012)
2 more