› 3dj9

X-ray diffraction
1.75Å resolution

Crystal Structure of an isolated, unglycosylated antibody CH2 domain

Released:
DOI: 10.2210/pdb3dj9/pdb
PDB entry 3dj9 coloured by chain, front view.
PDB entry 3dj9 coloured by chain, side view.
PDB entry 3dj9 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of an isolated unglycosylated antibody C(H)2 domain.
Prabakaran P, Vu BK, Gan J, Feng Y, Dimitrov DS, Ji X
OpenAccess logo Acta Crystallogr D Biol Crystallogr 64 1062-7 (2008)
PMID: 18931413

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134812 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Immunoglobulin heavy constant gamma 1 Chain: A
Molecule details ›
Chain: A
Length: 107 amino acids
Theoretical weight: 12.09 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01857 (Residues: 119-225; Coverage: 27%)
Gene name: IGHG1
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P21
Unit cell:
a: 36.144Å b: 40.678Å c: 39.131Å
α: 90° β: 106.74° γ: 90°
R-values:
R R work R free
0.203 0.201 0.227
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Engineered CH2 domains (nanoantibodies).
Dimitrov DS. (2009)
3 more

11 mentions without citation

Engineered human antibody constant domains with increased stability.
Gong et al. (2009)
10 more