› 3ebw

X-ray diffraction
2.8Å resolution

Crystal structure of major allergens, Per a 4 from cockroaches

Released:
DOI: 10.2210/pdb3ebw/pdb
Model geometry
Fit model/data
PDB entry 3ebw coloured by chain, front view.
PDB entry 3ebw coloured by chain, side view.
PDB entry 3ebw coloured by chain, top view.
Source organism: Periplaneta americana
Primary publication:
Structures of two major allergens, Bla g 4 and Per a 4, from cockroaches and their IgE binding epitopes.
Tan YW, Chan SL, Ong TC, Yit LY, Tiong YS, Chew FT, Sivaraman J, Mok YK
J Biol Chem 284 3148-3157 (2009)
PMID: 19056737

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
homo dimer
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172962 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Lipocalin/cytosolic fatty-acid binding domain-containing protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 163 amino acids
Theoretical weight: 18.72 KDa
Source organism: Periplaneta americana
Expression system: Escherichia coli
UniProt:
  • Canonical: Q1M0Y5 (Residues: 19-181; Coverage: 99%)
Sequence domains: Lipocalin-like domain
Structure domains: Lipocalin

Ligands and Environments

1 bound ligand:
Ligand PE4 2 x PE4
1 modified residue:
Ligand MSE 6 x MSE

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: NSLS BEAMLINE X12C
Spacegroup: P41
Unit cell:
a: 62.985Å b: 62.985Å c: 143.699Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.231 0.231 0.276
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Indoor Allergens and Allergic Respiratory Disease.
Pomés et al. (2016)
2 more

13 mentions without citation

Relevant B cell epitopes in allergic disease.
Pomés A. (2010)
12 more