› 3elz

X-ray diffraction
2.2Å resolution

Crystal structure of Zebrafish Ileal Bile Acid-Bindin Protein complexed with cholic acid (crystal form A).

Released:
DOI: 10.2210/pdb3elz/pdb
PDB entry 3elz coloured by chain, front view.
PDB entry 3elz coloured by chain, side view.
PDB entry 3elz coloured by chain, top view.
Source organism: Danio rerio
Primary publication:
The X-ray structure of zebrafish (Danio rerio) ileal bile acid-binding protein reveals the presence of binding sites on the surface of the protein molecule.
Capaldi S, Saccomani G, Fessas D, Signorelli M, Perduca M, Monaco HL
J Mol Biol 385 99-116 (2009)
PMID: 18952094

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-179762 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Gastrotropin Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 138 amino acids
Theoretical weight: 15.19 KDa
Source organism: Danio rerio
Expression system: Escherichia coli
UniProt:
  • Canonical: Q6IMW5 (Residues: 2-131; Coverage: 99%)
Gene names: fabp6, zgc:92421
Sequence domains: Lipocalin / cytosolic fatty-acid binding protein family
Structure domains: Lipocalin

Ligands and Environments

1 bound ligand:
Ligand CHD 13 x CHD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: C2
Unit cell:
a: 149.195Å b: 80.29Å c: 39.723Å
α: 90° β: 96.12° γ: 90°
R-values:
R R work R free
0.224 0.222 0.264
Expression system: Escherichia coli

Quick links

Citations

8 review citations

Intestinal transport and metabolism of bile acids.
Dawson et al. (2015)
7 more

1 mention without citation

Evidence that immunization with TP0751, a bipartite Treponema pallidum lipoprotein with an intrinsically disordered region and lipocalin fold, fails to protect in the rabbit model of experimental syphilis.
Luthra et al. (2020)