› 3eo0

X-ray diffraction
1.75Å resolution

Structure of the Transforming Growth Factor-Beta Neutralizing Antibody GC-1008

Released:
DOI: 10.2210/pdb3eo0/pdb
PDB entry 3eo0 coloured by chain, front view.
PDB entry 3eo0 coloured by chain, side view.
PDB entry 3eo0 coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
A cytokine-neutralizing antibody as a structural mimetic of 2 receptor interactions.
Grütter C, Wilkinson T, Turner R, Podichetty S, Finch D, McCourt M, Loning S, Jermutus L, Grütter MG
Proc Natl Acad Sci U S A 105 20251-6 (2008)
PMID: 19073914

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-234825 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
GC-1008 Fab Light Chain Chains: A, C
Molecule details ›
Chains: A, C
Length: 215 amino acids
Theoretical weight: 23.43 KDa
Source organism: Mus musculus
Expression system: Mus musculus
Structure domains: Immunoglobulins
Ig-like domain-containing protein Chains: B, D
Molecule details ›
Chains: B, D
Length: 225 amino acids
Theoretical weight: 23.85 KDa
Source organism: Mus musculus
Expression system: Mus musculus
UniProt:
  • Canonical: Q6PYX1 (Residues: 4-119; Coverage: 33%)
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand GOL 6 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P21
Unit cell:
a: 91.561Å b: 83.009Å c: 91.824Å
α: 90° β: 103.38° γ: 90°
R-values:
R R work R free
0.183 0.182 0.201
Expression system: Mus musculus

Quick links

Citations

13 review citations

Monoclonal antibodies: versatile platforms for cancer immunotherapy.
Weiner et al. (2010)
12 more

5 mentions without citation

Insights into the structure of class B GPCRs.
Hollenstein et al. (2014)
4 more