› 3fat

X-ray diffraction
1.9Å resolution

X-ray structure of iGluR4 flip ligand-binding core (S1S2) in complex with (S)-AMPA at 1.90A resolution

Released:
DOI: 10.2210/pdb3fat/pdb
PDB entry 3fat coloured by chain, front view.
PDB entry 3fat coloured by chain, side view.
PDB entry 3fat coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Molecular mechanism of agonist recognition by the ligand-binding core of the ionotropic glutamate receptor 4.
Kasper C, Frydenvang K, Naur P, Gajhede M, Pickering DS, Kastrup JS
FEBS Lett 582 4089-94 (2008)
PMID: 19022251

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148618 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor 4 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 260 amino acids
Theoretical weight: 29.02 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P19493 (Residues: 415-528, 654-796; Coverage: 29%)
  • Best match: P19493-2 (Residues: 415-528, 654-796)
Gene names: Glur4, Gria4
Sequence domains:
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

4 bound ligands:
Ligand AMQ 3 x AMQ
Ligand SO4 7 x SO4
Ligand GOL 9 x GOL
Ligand ACY 6 x ACY
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MAX II BEAMLINE I911-2
Spacegroup: C2
Unit cell:
a: 105.175Å b: 169.531Å c: 73.883Å
α: 90° β: 120.58° γ: 90°
R-values:
R R work R free
0.177 0.175 0.216
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Functional insights from glutamate receptor ion channel structures.
Kumar et al. (2013)
2 more