› 3fb3

X-ray diffraction
2.35Å resolution

Crystal Structure of Trypanosoma Brucei Acetyltransferase, Tb11.01.2886

Released:
DOI: 10.2210/pdb3fb3/pdb
PDB entry 3fb3 coloured by chain, front view.
PDB entry 3fb3 coloured by chain, side view.
PDB entry 3fb3 coloured by chain, top view.
Source organism: Trypanosoma brucei
Entry authors: Wernimont AK, Marino K, Zhang AZ, Ma D, Lin YH, MacKenzie F, Kozieradzki I, Cossar D, Zhao Y, Schapira M, Bochkarev A, Arrowsmith CH, Bountra C, Weigelt J, Edwards AM, Ferguson MAJ, Hui R, Qiu W, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
Acetyl-CoA + D-glucosamine 6-phosphate = CoA + N-acetyl-D-glucosamine 6-phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-122900 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glucosamine 6-phosphate N-acetyltransferase Chains: A, B
Molecule details ›
Chains: A, B
Length: 161 amino acids
Theoretical weight: 18.01 KDa
Source organism: Trypanosoma brucei
Expression system: Escherichia coli
UniProt:
  • Canonical: E3Q1H1 (Residues: 5-147; Coverage: 97%)
Gene name: GNA1
Sequence domains: Acetyltransferase (GNAT) family
Structure domains: Aminopeptidase

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E+ SUPERBRIGHT
Spacegroup: P43212
Unit cell:
a: 71.91Å b: 71.91Å c: 124.625Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.213 0.208 0.299
Expression system: Escherichia coli

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