› 3fwq

X-ray diffraction
2.3Å resolution

Inactive conformation of human protein kinase CK2 catalytic subunit

Released:
DOI: 10.2210/pdb3fwq/pdb
PDB entry 3fwq coloured by chain, front view.
PDB entry 3fwq coloured by chain, side view.
PDB entry 3fwq coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
First inactive conformation of CK2 alpha, the catalytic subunit of protein kinase CK2.
Raaf J, Issinger OG, Niefind K
J Mol Biol 386 1212-21 (2009)
PMID: 19361447

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159383 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Casein kinase II subunit alpha Chains: A, B
Molecule details ›
Chains: A, B
Length: 335 amino acids
Theoretical weight: 40.07 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P68400 (Residues: 1-335; Coverage: 86%)
Gene names: CK2A1, CSNK2A1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand GOL 3 x GOL
Ligand SO4 1 x SO4
Ligand CL 5 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X12
Spacegroup: P43
Unit cell:
a: 71.324Å b: 71.324Å c: 125.681Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.173 0.17 0.233
Expression system: Escherichia coli

Quick links

Citations

18 citation in other articles

Dynamic regulation of a metabolic multi-enzyme complex by protein kinase CK2.
An et al. (2010)
17 more

7 mentions without citation

Specific inhibition of CK2α from an anchor outside the active site.
Brear et al. (2016)
6 more