› 3g1u

X-ray diffraction
2.2Å resolution

Crystal structure of Leishmania major S-adenosylhomocysteine hydrolase

Released:
DOI: 10.2210/pdb3g1u/pdb
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PDB entry 3g1u coloured by chain, front view.
PDB entry 3g1u coloured by chain, side view.
PDB entry 3g1u coloured by chain, top view.
Source organism: Leishmania major
Entry authors: Siponen MI, Welin M, Arrowsmith CH, Berglund H, Bountra C, Collins R, Dahlgren LG, Edwards AM, Flodin S, Flores A, Graslund S, Hammarstrom M, Johansson A, Johansson I, Karlberg T, Kotenyova T, Lehtio L, Moche M, Nilsson ME, Nordlund P, Nyman T, Persson C, Sagemark J, Schutz P, Thorsell AG, Tresaugues L, Van Den Berg S, Weigelt J, Wisniewska M, Schueler H, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-175663 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Adenosylhomocysteinase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 437 amino acids
Theoretical weight: 47.89 KDa
Source organism: Leishmania major
Expression system: Escherichia coli
UniProt:
  • Canonical: Q4Q124 (Residues: 1-437; Coverage: 100%)
Gene name: LMJF_36_3910
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand ADN 4 x ADN
Ligand NAD 4 x NAD
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P1
Unit cell:
a: 72.38Å b: 82.47Å c: 83.88Å
α: 87.02° β: 71.41° γ: 74°
R-values:
R R work R free
0.184 0.182 0.232
Expression system: Escherichia coli

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