› 3gbo

X-ray diffraction
1.77Å resolution

Crystal structure of BmooMPalpha-I, a non-hemorrhagic metalloproteinase isolated from Bothrops moojeni snake venom

Released:
DOI: 10.2210/pdb3gbo/pdb
PDB entry 3gbo coloured by chain, front view.
PDB entry 3gbo coloured by chain, side view.
PDB entry 3gbo coloured by chain, top view.
Source organism: Bothrops moojeni
Primary publication:
Structural studies of BmooMPalpha-I, a non-hemorrhagic metalloproteinase from Bothrops moojeni venom.
Akao PK, Tonoli CC, Navarro MS, Cintra AC, Neto JR, Arni RK, Murakami MT
Toxicon 55 361-8 (2010)
PMID: 19706302

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160949 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Snake venom metalloproteinase BmooMPalpha-I Chain: A
Molecule details ›
Chain: A
Length: 200 amino acids
Theoretical weight: 22.7 KDa
Source organism: Bothrops moojeni
UniProt:
  • Canonical: P85314 (Residues: 5-204; Coverage: 98%)
Sequence domains: Reprolysin (M12B) family zinc metalloprotease
Structure domains: Collagenase (Catalytic Domain)

Ligands and Environments

2 bound ligands:
Ligand CA 1 x CA
Ligand ZN 1 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: LNLS BEAMLINE D03B-MX1
Spacegroup: P21
Unit cell:
a: 40.074Å b: 48.732Å c: 54.393Å
α: 90° β: 91.56° γ: 90°
R-values:
R R work R free
0.179 0.172 0.218

Quick links

Citations

6 review citations

Snake venoms: attractive antimicrobial proteinaceous compounds for therapeutic purposes.
de Oliveira Junior et al. (2013)
5 more

6 mentions without citation

ADAM and ADAMTS Family Proteins and Snake Venom Metalloproteinases: A Structural Overview.
Takeda S. (2016)
5 more