› 3gin

X-ray diffraction
2.4Å resolution

Crystal structure of E454K-CBD1

Released:
DOI: 10.2210/pdb3gin/pdb
PDB entry 3gin coloured by chain, front view.
PDB entry 3gin coloured by chain, side view.
PDB entry 3gin coloured by chain, top view.
Source organism: Canis lupus familiaris
Primary publication:
Structure and functional analysis of a Ca2+ sensor mutant of the Na+/Ca2+ exchanger.
Chaptal V, Ottolia M, Mercado-Besserer G, Nicoll DA, Philipson KD, Abramson J
J Biol Chem 284 14688-92 (2009)
PMID: 19332552

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150039 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sodium/calcium exchanger 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 160 amino acids
Theoretical weight: 17.46 KDa
Source organism: Canis lupus familiaris
Expression system: Escherichia coli
UniProt:
  • Canonical: P23685 (Residues: 402-541; Coverage: 15%)
Gene names: NCX1, SLC8A1
Sequence domains: Calx-beta domain
Structure domains: Immunoglobulin-like

Ligands and Environments

1 bound ligand:
Ligand CA 7 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1
Spacegroup: P41212
Unit cell:
a: 91.858Å b: 91.858Å c: 65.59Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.196 0.193 0.259
Expression system: Escherichia coli

Quick links

Citations

6 review citations

The SLC8 gene family of sodium-calcium exchangers (NCX) - structure, function, and regulation in health and disease.
Khananshvili D. (2013)
5 more

2 mentions without citation

A common Ca2+-driven interdomain module governs eukaryotic NCX regulation.
Giladi et al. (2012)
1 more