› 3giv

X-ray diffraction
2Å resolution

Antigen processing influences HIV-specific cytotoxic T lymphocyte immunodominance

Released:
DOI: 10.2210/pdb3giv/pdb
PDB entry 3giv coloured by chain, front view.
PDB entry 3giv coloured by chain, side view.
PDB entry 3giv coloured by chain, top view.
Source organisms:
Primary publication:
Antigen processing influences HIV-specific cytotoxic T lymphocyte immunodominance.
Tenzer S, Wee E, Burgevin A, Stewart-Jones G, Friis L, Lamberth K, Chang CH, Harndahl M, Weimershaus M, Gerstoft J, Akkad N, Klenerman P, Fugger L, Jones EY, McMichael AJ, Buus S, Schild H, van Endert P, Iversen AK
Nat Immunol 10 636-46 (2009)
PMID: 19412183

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-137839 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
HLA class I histocompatibility antigen, A alpha chain Chains: A, D
Molecule details ›
Chains: A, D
Length: 275 amino acids
Theoretical weight: 31.85 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P04439 (Residues: 25-299; Coverage: 81%)
Gene names: HLA-A, HLAA
Sequence domains:
Structure domains:
Beta-2-microglobulin Chains: B, E
Molecule details ›
Chains: B, E
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
Immunodeficiency lentiviral matrix N-terminal domain-containing protein Chains: C, F
Molecule details ›
Chains: C, F
Length: 10 amino acids
Theoretical weight: 1.13 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Not provided
UniProt:
  • Canonical: Q9YYH6 (Residues: 50-59; Coverage: 7%)
Gene name: gag

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P21
Unit cell:
a: 79.581Å b: 88.185Å c: 63.864Å
α: 90° β: 90.04° γ: 90°
R-values:
R R work R free
0.196 0.194 0.238
Expression system: Not provided

Quick links

Citations

32 review citations

The immune response during acute HIV-1 infection: clues for vaccine development.
McMichael et al. (2010)
31 more

3 mentions without citation

Predicting Antigen Presentation-What Could We Learn From a Million Peptides?
Gfeller et al. (2018)
2 more