3gvb

X-ray diffraction
1.8Å resolution

AmpC beta-lactamase in complex with Fragment-based Inhibitor

Released:
Source organism: Escherichia coli K-12
Primary publication:
Docking for fragment inhibitors of AmpC beta-lactamase.
Proc Natl Acad Sci U S A 106 7455-60 (2009)
PMID: 19416920

Function and Biology Details

Reaction catalysed:
A beta-lactam + H(2)O = a substituted beta-amino acid
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133599 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Beta-lactamase Chains: A, B
Molecule details ›
Chains: A, B
Length: 358 amino acids
Theoretical weight: 39.59 KDa
Source organism: Escherichia coli K-12
Expression system: Escherichia coli
UniProt:
  • Canonical: P00811 (Residues: 20-377; Coverage: 100%)
Gene names: JW4111, ampA, ampC, b4150
Sequence domains: Beta-lactamase
Structure domains: DD-peptidase/beta-lactamase superfamily

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: C2
Unit cell:
a: 118.109Å b: 76.177Å c: 97.522Å
α: 90° β: 116.51° γ: 90°
R-values:
R R work R free
0.208 0.207 0.226
Expression system: Escherichia coli