Function and Biology Details
Reaction catalysed:
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
Biochemical function:
- not assigned
Biological process:
Cellular component:
Sequence domains:
- Beta-adaptin appendage, C-terminal subdomain
- Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain
- Coatomer/calthrin adaptor appendage, C-terminal subdomain
- TBP domain superfamily
- Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain
- Clathrin adaptor, appendage, Ig-like subdomain superfamily
- AP complex subunit beta
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-129942 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
AP-2 complex subunit beta
Molecule details ›
Chain: A
Length: 260 amino acids
Theoretical weight: 29.25 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
Sequence domains:
Structure domains:
Length: 260 amino acids
Theoretical weight: 29.25 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
- Canonical:
P62944 (Residues: 701-937; Coverage: 25%)
Sequence domains:
Structure domains:
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma
Molecule details ›
Chain: P
Length: 15 amino acids
Theoretical weight: 1.9 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
Length: 15 amino acids
Theoretical weight: 1.9 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
- Canonical: O60331 (Residues: 639-653; Coverage: 2%)
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
BESSY BEAMLINE 14.1
Spacegroup:
P212121
Expression systems:
- Escherichia coli
- Not provided
