› 3h7f

X-ray diffraction
1.5Å resolution

Function and Biology Details

Reaction catalysed: 
5,10-methylenetetrahydrofolate + glycine + H(2)O = tetrahydrofolate + L-serine
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161491 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine hydroxymethyltransferase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 447 amino acids
Theoretical weight: 47.6 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Escherichia coli
UniProt:
  • Canonical: P9WGI9 (Residues: 13-438; Coverage: 97%)
Gene names: MTV017.46, Rv1093, glyA, glyA1
Sequence domains: Serine hydroxymethyltransferase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand MG 1 x MG
1 modified residue:
Ligand LLP 2 x LLP

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.3
Spacegroup: P212121
Unit cell:
a: 60.73Å b: 102.01Å c: 132.12Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.166 0.165 0.196
Expression system: Escherichia coli

Quick links

Citations

6 review citations

Pleiotropic Functions of Tumor Suppressor WWOX in Normal and Cancer Cells.
Abu-Remaileh et al. (2015)
5 more

4 mentions without citation

Phylogenetic framework and molecular signatures for the main clades of the phylum Actinobacteria.
Gao et al. (2012)
3 more