› 3j2s

Electron Microscopy
15Å resolution

Membrane-bound factor VIII light chain

Released:
DOI: 10.2210/pdb3j2s/pdb
PDB entry 3j2s coloured by chain, front view.
PDB entry 3j2s coloured by chain, side view.
PDB entry 3j2s coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Domain organization of membrane-bound factor VIII.
Stoilova-McPhie S, Lynch GC, Ludtke S, Pettitt BM
Biopolymers 99 448-59 (2013)
PMID: 23616213
Related structures: EMD-5559

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132518 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Factor VIIIa light chain Chain: B
Molecule details ›
Chain: B
Length: 642 amino acids
Theoretical weight: 74.04 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P00451 (Residues: 1710-2351; Coverage: 28%)
Gene names: F8, F8C
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 15Å
Relevant EMDB volumes: EMD-5559
Expression system: Cricetulus griseus

Quick links

Citations

4 review citations

Life in the shadow of a dominant partner: the FVIII-VWF association and its clinical implications for hemophilia A.
Pipe et al. (2016)
3 more

3 mentions without citation

Uncovering Membrane-Bound Models of Coagulation Factors by Combined Experimental and Computational Approaches.
Ohkubo et al. (2021)
2 more