› 3jcb

Electron Microscopy

Structure of Simian Immunodeficiency Virus Envelope Spikes bound with CD4 and Monoclonal Antibody 36D5

Released:
DOI: 10.2210/pdb3jcb/pdb
PDB entry 3jcb coloured by chain, front view.
PDB entry 3jcb coloured by chain, side view.
PDB entry 3jcb coloured by chain, top view.
Source organisms:
Primary publication:
Structure of Simian Immunodeficiency Virus Envelope Spikes Bound with CD4 and Monoclonal Antibody 36D5.
Hu G, Liu J, Roux KH, Taylor KA
J Virol 91 (2017)
PMID: 28539445
Related structures: EMD-6542

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
PDBe Complex ID:
PDB-CPX-207447 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Human immunodeficiency virus 1 envelope glycoprotein Gp120 domain-containing protein Chains: A, E, I
Molecule details ›
Chains: A, E, I
Length: 448 amino acids
Theoretical weight: 50.13 KDa
Source organism: Simian immunodeficiency virus
UniProt:
  • Canonical: A0A3B6UDT5 (Residues: 1-448; Coverage: 100%)
Sequence domains: Envelope glycoprotein GP120
Antibody 36D5 light chain Chain: B
Molecule details ›
Chain: B
Length: 207 amino acids
Theoretical weight: 22.29 KDa
Source organism: Homo sapiens
Antibody 36D5 heavy chain Chain: C
Molecule details ›
Chain: C
Length: 232 amino acids
Theoretical weight: 25.12 KDa
Source organism: Homo sapiens
T-cell surface glycoprotein CD4 Chain: D
Molecule details ›
Chain: D
Length: 175 amino acids
Theoretical weight: 19.44 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P01730 (Residues: 26-200; Coverage: 40%)
Gene name: CD4
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Relevant EMDB volumes: EMD-6542

Quick links

Citations

6 citation in other articles

HIV-1 Env trimer opens through an asymmetric intermediate in which individual protomers adopt distinct conformations.
Ma et al. (2018)
5 more

1 mention without citation

Structure of Simian Immunodeficiency Virus Envelope Spikes Bound with CD4 and Monoclonal Antibody 36D5.
Hu et al. (2017)