› 3l88

X-ray diffraction
2.5Å resolution

Crystal structure of the human Adenovirus type 21 fiber knob

Released:
DOI: 10.2210/pdb3l88/pdb
PDB entry 3l88 coloured by chain, front view.
PDB entry 3l88 coloured by chain, side view.
PDB entry 3l88 coloured by chain, top view.
Source organism: Human adenovirus 21
Primary publication:
Structure of adenovirus type 21 knob in complex with CD46 reveals key differences in receptor contacts among species B adenoviruses.
Cupelli K, Müller S, Persson BD, Jost M, Arnberg N, Stehle T
J Virol 84 3189-200 (2010)
PMID: 20071571

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-173696 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Adenoviral fibre protein knob domain-containing protein Chains: A, B, C, D, E, F, G, H, I, J, K, L
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L
Length: 201 amino acids
Theoretical weight: 22.22 KDa
Source organism: Human adenovirus 21
Expression system: Escherichia coli
UniProt:
  • Canonical: Q2KS96 (Residues: 123-323; Coverage: 62%)
Gene name: L5
Sequence domains: Adenoviral fibre protein (knob domain)
Structure domains: Adenovirus pIV-related, attachment domain

Ligands and Environments

3 bound ligands:
Ligand NA 11 x NA
Ligand GOL 4 x GOL
Ligand CL 2 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P2
Unit cell:
a: 85Å b: 63.92Å c: 209.35Å
α: 90° β: 91.7° γ: 90°
R-values:
R R work R free
0.235 0.234 0.259
Expression system: Escherichia coli

Quick links

Citations

11 review citations

Viral quasispecies evolution.
Domingo et al. (2012)
10 more

2 mentions without citation

Updates to the Integrated Protein-Protein Interaction Benchmarks: Docking Benchmark Version 5 and Affinity Benchmark Version 2.
Vreven et al. (2015)
1 more