› 3lyl

X-ray diffraction
1.95Å resolution

Structure of 3-oxoacyl-acylcarrier protein reductase, FabG from Francisella tularensis

Released:
DOI: 10.2210/pdb3lyl/pdb
PDB entry 3lyl coloured by chain, front view.
PDB entry 3lyl coloured by chain, side view.
PDB entry 3lyl coloured by chain, top view.
Source organism: Francisella tularensis subsp. tularensis SCHU S4
Entry authors: Anderson SM, Wawrzak Z, Gordon E, Hasseman J, Edwards A, Savchenko A, Anderson WF, Center for Structural Genomics of Infectious Diseases (CSGID)

Function and Biology Details

Reaction catalysed: 
(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP(+) = 3-oxoacyl-[acyl-carrier-protein] + NADPH
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-177657 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
3-oxoacyl-[acyl-carrier-protein] reductase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 247 amino acids
Theoretical weight: 26.9 KDa
Source organism: Francisella tularensis subsp. tularensis SCHU S4
Expression system: Escherichia coli
UniProt:
  • Canonical: Q5NF68 (Residues: 1-247; Coverage: 100%)
Gene names: FTT_1375, fabG
Sequence domains: Enoyl-(Acyl carrier protein) reductase
Structure domains: NAD(P)-binding Rossmann-like Domain

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 44 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: P21
Unit cell:
a: 71.766Å b: 86.941Å c: 77.522Å
α: 90° β: 98.316° γ: 90°
R-values:
R R work R free
0.201 0.199 0.243
Expression system: Escherichia coli

Quick links