3n4w

X-ray diffraction
1.45Å resolution

Crystal structure of an abridged SER to ALA mutant of the mature ectodomain of the human receptor-type protein-tyrosine phosphatase ICA512/IA-2 at pH 7.5

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
PDBe Complex ID:
PDB-CPX-172595 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ICA512-transmembrane fragment Chains: A, B
Molecule details ›
Chains: A, B
Length: 89 amino acids
Theoretical weight: 9.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q16849 (Residues: 470-558; Coverage: 9%)
Gene names: ICA3, ICA512, PTPRN
Sequence domains: Protein-tyrosine phosphatase receptor IA-2
Structure domains: Protein-tyrosine phosphatase receptor IA-2 ectodomain

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X6A
Spacegroup: P212121
Unit cell:
a: 31.472Å b: 66.016Å c: 73.65Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.187 0.185 0.227
Expression system: Escherichia coli BL21(DE3)