› 3nnv

X-ray diffraction
2.1Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172487 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitogen-activated protein kinase 14 Chain: A
Molecule details ›
Chain: A
Length: 354 amino acids
Theoretical weight: 40.61 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q16539 (Residues: 1-354; Coverage: 98%)
Gene names: CSBP, CSBP1, CSBP2, CSPB1, MAPK14, MXI2, SAPK2A
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand 437 1 x 437
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-BM
Spacegroup: P212121
Unit cell:
a: 45.561Å b: 86.334Å c: 125.774Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.188 0.186 0.235
Expression system: Spodoptera frugiperda

Quick links

Citations

3 review citations

Targeted therapy in GIST: in silico modeling for prediction of resistance.
Pierotti et al. (2011)
2 more

4 mentions without citation

Structural and evolutionary divergence of eukaryotic protein kinases in Apicomplexa.
Talevich et al. (2011)
3 more